The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease1s⃞

Guenther Silbernagel; Guenter Fauler; Wilfried Renner; Eva M. Landl; Michael M. Hoffmann; Bernhard R. Winkelmann; Bernhard O. Boehm; Winfried März

Journal of Lipid Research (Feb 2009)

The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease1s⃞

Guenther Silbernagel,
Guenter Fauler,
Wilfried Renner,
Eva M. Landl,
Michael M. Hoffmann,
Bernhard R. Winkelmann,
Bernhard O. Boehm,
Winfried März

Affiliations

Guenther Silbernagel: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
Guenter Fauler: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
Wilfried Renner: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
Eva M. Landl: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
Michael M. Hoffmann: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
Bernhard R. Winkelmann: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
Bernhard O. Boehm: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
Winfried März: Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Division of Clinical Chemistry, Department of Internal Medicine, University of Freiburg, Freiburg, Germany; Cardiology Group Frankfurt-Sachsenhausen, Frankfurt, Germany; Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Synlab Center of Laboratory Diagnostics, Heidelberg, Germany

Journal volume & issue: Vol. 50, no. 2
pp. 334 – 341

Abstract

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Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease (CAD) in 2,440 participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. The coronary status was determined by angiography, and the severity of CAD was assessed by the Friesinger Score (FS). An increase in the ratio of cholestanol to cholesterol was associated with high FS (P = 0.006). In contrast, a high ratio of lathosterol to cholesterol went in parallel with low FS (P < 0.001). Whereas the campesterol to cholesterol ratio significantly correlated with the FS (P = 0.026), the relationship of the sitosterol to cholesterol ratio with the FS did not reach statistical significance in the whole group. Increased campesterol, sitosterol, and cholestanol to lathosterol ratios were associated high FS (P < 0.001). To conclude, there is a modest association of high cholesterol absorption and low cholesterol synthesis with an increased severity of CAD. An atherogenic role of plasma plant sterols themselves, however, seems unlikely in subjects without sitosterolaemia.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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