Journal of Clinical Medicine (May 2021)

Osteoglycin as a Potential Biomarker of Mild Kidney Function Impairment in Type 2 Diabetes Patients

  • Sheila González-Salvatierra,
  • Cristina García-Fontana,
  • Francisco Andújar-Vera,
  • Alejandro Borja Grau-Perales,
  • Luis Martínez-Heredia,
  • María Dolores Avilés-Pérez,
  • María Hayón-Ponce,
  • Iván Iglesias-Baena,
  • Blanca Riquelme-Gallego,
  • Manuel Muñoz-Torres,
  • Beatriz García-Fontana

DOI
https://doi.org/10.3390/jcm10102209
Journal volume & issue
Vol. 10, no. 10
p. 2209

Abstract

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Osteoglycin (OGN) could be a biomarker of mild kidney function impairment in type 2 diabetes (T2D). Our study aimed to determine the association between serum OGN and impaired kidney function risk in T2D patients and to analyze its potential role as an estimator of kidney disturbances in this population. This cross-sectional study included 147 T2D patients (65 ± 8 years, 58.5% males), and 75 healthy controls (63 ± 10 years, 36% males). Circulating OGN levels were determined by ELISA. Linear regression modeling was performed to determine the variables influencing circulating OGN, and an ROC curve was plotted to assess the usefulness of OGN as an estimator of diabetic kidney disease risk. Circulating OGN was significantly increased in T2D patients compared to controls (18.41 (14.45–23.27) ng/mL vs. 8.74 (7.03–12.35) ng/mL; p p = 0.006). Circulating OGN was an independent estimator of mildly impaired kidney function risk in T2D patients. We suggest that serum OGN could act as an albuminuria-independent biomarker of incipient kidney dysfunction in T2D patients.

Keywords