Communications Biology (Feb 2021)
The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
- Sensen Zhang,
- Jun Zhou,
- Yuebin Zhang,
- Tianya Liu,
- Perrine Friedel,
- Wei Zhuo,
- Suma Somasekharan,
- Kasturi Roy,
- Laixing Zhang,
- Yang Liu,
- Xianbin Meng,
- Haiteng Deng,
- Wenwen Zeng,
- Guohui Li,
- Biff Forbush,
- Maojun Yang
Affiliations
- Sensen Zhang
- Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
- Jun Zhou
- Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
- Yuebin Zhang
- State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Tianya Liu
- Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
- Perrine Friedel
- Department of Cellular and Molecular Physiology, Yale University School of Medicine
- Wei Zhuo
- Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
- Suma Somasekharan
- Department of Cellular and Molecular Physiology, Yale University School of Medicine
- Kasturi Roy
- Department of Cellular and Molecular Physiology, Yale University School of Medicine
- Laixing Zhang
- Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
- Yang Liu
- Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
- Xianbin Meng
- MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University
- Haiteng Deng
- MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University
- Wenwen Zeng
- Center for Life Sciences, Institute for Immunology and School of Medicine, Tsinghua University
- Guohui Li
- State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Biff Forbush
- Department of Cellular and Molecular Physiology, Yale University School of Medicine
- Maojun Yang
- Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
- DOI
- https://doi.org/10.1038/s42003-021-01750-w
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 15
Abstract
Zhang et al. present the cryo-electron microscopy structures of the two neuronal cation-chloride cotransporters human NKCC1 and mouse KCC2, identifying their essential residues for ion transport. This study proposes mechanisms by which phosphorylation regulates the activity of these cation-chloride cotransporters.
