Oral submucous fibrosis: A case report and contemporary review of pathogenesis

Abstract

Oral submucous fibrosis (OSF) is an oral potentially malignant disorder characterized by fibroelastic changes in the juxta-epithelial layer leading to trismus. Areca nut and its metabolites contribute to the etiopathogenesis. We report a case of a 53-year-old male patient with burning sensation and reduced mouth opening. Clinical findings and histopathologic findings were consistent with the diagnosis of OSF – intermediate stage. The patient was conservatively managed with lycopene 4 mg twice daily for 3 months and also advised oral physiotherapy. The patient was educated on the effects of areca nut and chances of malignant transformation.

Keywords

• malignant transformation
• oral submucous fibrosis
• pathogenesis