Stem Cell Research (Jul 2021)

Generation of IBMS-iPSC-015, -016, -017 human induced pluripotent stem cells (IBMSi013-A, IBMSi014-A, and IBMSi015-A) derived from patients with atrial fibrillation

  • Yueh-Ting Chiu,
  • Ming-Heng Tsai,
  • Darien Zhing-Herr Chan,
  • Hui-Wen Ko,
  • Huai-En Lu,
  • Chi-Ying F. Huang,
  • Yenn-Jiang Lin,
  • Shih-Lin Chang,
  • Li-Wei Lo,
  • Ching-Ying Huang,
  • Yu-Feng Hu,
  • Patrick C.H. Hsieh,
  • Shih-Ann Chen

Journal volume & issue
Vol. 54
p. 102419

Abstract

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Atrial fibrillation is the most common heart disease in the world, with around 35 million patients in 2020. Here we reported the generation of IBMS-iPSC-015-06, IBMS-iPSC-016-06, and IBMS-iPSC-017-02 as human induced pluripotent stem cell (iPSC) lines from patients’ peripheral blood mononuclear cells (PBMCs) with atrial fibrillation. The cell lines expressed properties of pluripotent stem cells, including pluripotent markers and the ability to differentiate into three germ layers. These cell lines served as suitable models for studying alternative therapies of atrial fibrillation.