Journal of Tropical Life Science (May 2015)

THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.

  • Nina Artanti,
  • Muhammad Hanafi,
  • Rina Andriyani,
  • Vienna Saraswati,
  • Zalinar Udin,
  • Puspa D. Lotulung,
  • Ken Ichi Fujita,
  • Yoshinosuke Usuki

Journal volume & issue
Vol. 5, no. 2
pp. 88 – 91


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Hedyotis corymbosa L., with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine. The ethanol extract of H. corymbosa L. shows inhibitory activity to humanYMB-1 breast cancer cell line with an IC50 of 6.51 μg/mL. The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 μg/mL. To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 μg/mL, respectively. Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.