mSystems (Aug 2021)

Catching SARS-CoV-2 by Sequence Hybridization: a Comparative Analysis

  • Alexandra Rehn,
  • Peter Braun,
  • Mandy Knüpfer,
  • Roman Wölfel,
  • Markus H. Antwerpen,
  • Mathias C. Walter

DOI
https://doi.org/10.1128/mSystems.00392-21
Journal volume & issue
Vol. 6, no. 4

Abstract

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Sequencing the genomes of the circulating SARS-CoV-2 strains is the only way to monitor the viral spread and evolution of the virus. Two different approaches, namely, tiling multiplex PCR and sequence hybridization by bait capture, are commonly used to fulfill this task.