Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice
Hsiu-Man Lien,
Yu-Yen Wang,
Mei-Zi Huang,
Hui-Yu Wu,
Chao-Lu Huang,
Chia-Chi Chen,
Shao-Wen Hung,
Chia-Chang Chen,
Cheng-Hsun Chiu,
Chih-Ho Lai
Affiliations
Hsiu-Man Lien
Research Institute of Biotechnology, Hungkuang University, Taichung 433304, Taiwan
Yu-Yen Wang
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Mei-Zi Huang
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Hui-Yu Wu
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Chao-Lu Huang
Department of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan
Chia-Chi Chen
Animal Technology Research Center, Agricultural Technology Research Institute, Hsinchu 300110, Taiwan
Shao-Wen Hung
Animal Technology Research Center, Agricultural Technology Research Institute, Hsinchu 300110, Taiwan
Chia-Chang Chen
School of Management, Feng Chia University, Taichung 407102, Taiwan
Cheng-Hsun Chiu
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Chih-Ho Lai
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the Helicobacter pylori infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-H. pylori and anti-gastric cancer activities of Anisomeles indica, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of A. indica on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted A. indica inhibited aspirin-induced gastric injury. Among these, A. indica Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that A. indica could be developed as an effective therapeutic agent for gastroprotective purposes.
