Nature Communications (Nov 2018)
PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
- Luke Russell,
- Jessica Swanner,
- Alena Cristina Jaime-Ramirez,
- Yufeng Wang,
- Alex Sprague,
- Yeshavanth Banasavadi-Siddegowda,
- Ji Young Yoo,
- Gina M. Sizemore,
- Raleigh Kladney,
- Jianying Zhang,
- Norman L. Lehman,
- Michael C Ostrowski,
- Bangxing Hong,
- Michael Caligiuri,
- Jianhua Yu,
- Balveen Kaur
Affiliations
- Luke Russell
- Department of Neurological Surgery, Ohio State University Comprehensive Cancer Center
- Jessica Swanner
- Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston
- Alena Cristina Jaime-Ramirez
- Department of Neurological Surgery, Ohio State University Comprehensive Cancer Center
- Yufeng Wang
- Department of Molecular Genetics, Ohio State University Comprehensive Cancer Center
- Alex Sprague
- Department of Neurological Surgery, Ohio State University Comprehensive Cancer Center
- Yeshavanth Banasavadi-Siddegowda
- Department of Neurological Surgery, Ohio State University Comprehensive Cancer Center
- Ji Young Yoo
- Department of Neurological Surgery, Ohio State University Comprehensive Cancer Center
- Gina M. Sizemore
- Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center
- Raleigh Kladney
- Department of Molecular Genetics, Ohio State University Comprehensive Cancer Center
- Jianying Zhang
- Division of Biostatistics, Department of Information Sciences, City of Hope National Medical Center
- Norman L. Lehman
- Department of Pathology and Laboratory Medicine, The Brown Cancer Center, University of Louisville
- Michael C Ostrowski
- Hollings Cancer Center, Department of Biochemistry and Molecular Biology, Medical University of South Carolina
- Bangxing Hong
- Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston
- Michael Caligiuri
- Department of Hematology & Hematopoietic Cell Transplantation,, City of Hope National Medical Center and Beckman Research Institute
- Jianhua Yu
- Department of Hematology & Hematopoietic Cell Transplantation,, City of Hope National Medical Center and Beckman Research Institute
- Balveen Kaur
- Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston
- DOI
- https://doi.org/10.1038/s41467-018-07344-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Oncolytic viruses are a promising therapeutic approach for cancer treatment. The authors demonstrate the efficacy of an engineered HSV-1 expressing PTENα as an oncolytic and immune stimulating therapy against brain cancer metastases.
