International Journal of Molecular Sciences (Dec 2022)

The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma

  • Shengjian Jin,
  • Yasusei Kudo,
  • Taigo Horiguchi

Journal volume & issue
Vol. 24, no. 1
p. 552


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Ubiquitination and deubiquitination are two popular ways for the post-translational modification of proteins. These two modifications affect intracellular localization, stability, and function of target proteins. The process of deubiquitination is involved in histone modification, cell cycle regulation, cell differentiation, apoptosis, endocytosis, autophagy, and DNA repair after damage. Moreover, it is involved in the processes of carcinogenesis and cancer development. In this review, we discuss these issues in understanding deubiquitinating enzyme (DUB) function in head and neck squamous cell carcinoma (HNSCC), and their potential therapeutic strategies for HNSCC patients are also discussed.