Formation of biofilms in human biotope microbiocenosis: model for prognostic calculations of intermicrobial relationships

Abstract

Comparative ranging analysis of mixed microbial biofilm forming by microbes from the same biotope is performed on the example of lactobacilli and yeast-like fungi (Candida species). Lactobacillus species (L. acidophilus, L. casei) leader strains influencing yeast-like fungal specie-depended biofilms were established. L. acidophilus and L. casei leader strains completed each other and revealed opposite regulating properties in respect of biofilm forming by С. albicans and C. tropicalis strains. In comparison to unity of positions C. tropicalis strains (all strains as the unite block in ranging sequence) according to their biofilm forming, two С. albicans subspecie populations (two blocks with higher and lower biofilm forming) were identified in biofilm ranging sequences. Results indicate perspectivity of ranging biofilm forming (by coupled cultures of potentially antagonistic microorganisms)

Keywords

• biofilms
• probiotics
• pathogens
• microbiocenosis
• biotope
• human