The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis

Abstract

Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor virus life cycle. HTLV-1 does not encode miRNA, but several studies have demonstrated that cellular miRNA expression is affected in infected cells. Distinct mechanisms such as transcriptional, epigenetic or interference with miRNA processing machinery have been involved. This article reviews the current knowledge of the role of cellular microRNAs in virus infection, replication, immune escape and pathogenesis of HTLV-1.

Keywords

• human
• HTLV-I infections
• T-lymphotrophic virus 1
• leukemia-lymphoma
• adult T-cell
• microRNAs
• virus replication
• cell line
• cell transformation
• gene expression regulation