The Innovation (Jan 2022)
Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China
- Qianyun Liu,
- Qing Xiong,
- Fanghua Mei,
- Chengbao Ma,
- Zhen Zhang,
- Bing Hu,
- Junqiang Xu,
- Yongzhong Jiang,
- Faxian Zhan,
- Suhua Zhou,
- Li Tao,
- Xianying Chen,
- Ming Guo,
- Xin Wang,
- Yaohui Fang,
- Shu Shen,
- Yingle Liu,
- Fang Liu,
- Li Zhou,
- Ke Xu,
- Changwen Ke,
- Fei Deng,
- Kun Cai,
- Huan Yan,
- Yu Chen,
- Ke Lan
Affiliations
- Qianyun Liu
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Qing Xiong
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Fanghua Mei
- Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
- Chengbao Ma
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Zhen Zhang
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Bing Hu
- Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
- Junqiang Xu
- Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
- Yongzhong Jiang
- Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
- Faxian Zhan
- Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
- Suhua Zhou
- Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
- Li Tao
- Wuhan Jiang'an District Center for Disease Control and Prevention, Wuhan 430000, China
- Xianying Chen
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Ming Guo
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Xin Wang
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Yaohui Fang
- National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
- Shu Shen
- National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
- Yingle Liu
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Fang Liu
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Li Zhou
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Ke Xu
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China
- Changwen Ke
- Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China
- Fei Deng
- National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
- Kun Cai
- Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China; Corresponding author
- Huan Yan
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China; Corresponding author
- Yu Chen
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China; Corresponding author
- Ke Lan
- State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China; Corresponding author
- Journal volume & issue
-
Vol. 3,
no. 1
p. 100181
Abstract
Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity, but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants. Here, we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan, the earliest known epicenter. SARS-CoV-2 immunoglobulin G (IgG) was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant. However, varying degrees of immune escape was observed on the other tested variants in a patient-specific manner, with individuals showing remarkably broad neutralization potency. The immune escape can be largely attributed to several critical spike mutations. These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants.
