Nature Communications (May 2022)
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
- Nicole Kiweler,
- Catherine Delbrouck,
- Vitaly I. Pozdeev,
- Laura Neises,
- Leticia Soriano-Baguet,
- Kim Eiden,
- Feng Xian,
- Mohaned Benzarti,
- Lara Haase,
- Eric Koncina,
- Maryse Schmoetten,
- Christian Jaeger,
- Muhammad Zaeem Noman,
- Alexei Vazquez,
- Bassam Janji,
- Gunnar Dittmar,
- Dirk Brenner,
- Elisabeth Letellier,
- Johannes Meiser
Affiliations
- Nicole Kiweler
- Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health
- Catherine Delbrouck
- Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health
- Vitaly I. Pozdeev
- Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg
- Laura Neises
- Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health
- Leticia Soriano-Baguet
- Faculty of Science, Technology and Medicine, University of Luxembourg, 2 avenue de Université
- Kim Eiden
- Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health
- Feng Xian
- Proteomics of cellular signaling, Department of Infection and Immunity, Luxembourg Institute of Health,1a Rue Thomas Edison
- Mohaned Benzarti
- Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health
- Lara Haase
- Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health
- Eric Koncina
- Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg
- Maryse Schmoetten
- Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg
- Christian Jaeger
- Luxembourg Centre for Systems Biomedicine, University of Luxembourg
- Muhammad Zaeem Noman
- Tumor Immunotherapy and Microenvironment (TIME) Group, Department of Cancer Research, Luxembourg Institute of Health
- Alexei Vazquez
- Institute of Cancer Sciences, University of Glasgow
- Bassam Janji
- Tumor Immunotherapy and Microenvironment (TIME) Group, Department of Cancer Research, Luxembourg Institute of Health
- Gunnar Dittmar
- Faculty of Science, Technology and Medicine, University of Luxembourg, 2 avenue de Université
- Dirk Brenner
- Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health
- Elisabeth Letellier
- Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg
- Johannes Meiser
- Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health
- DOI
- https://doi.org/10.1038/s41467-022-30363-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Chemotherapeutic antifolates, such as methotrexate (MTX), impair cancer cell proliferation by inhibiting nucleotide synthesis. Here, the authors show that MTX sustains an autarkic mitochondrial one-carbon metabolism leading to serine synthesis to promote cancer cell migration and metastasis.
