Nature Communications (Dec 2021)
Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling
- Joel Zindel,
- Jonas Mittner,
- Julia Bayer,
- Simon L. April-Monn,
- Andreas Kohler,
- Ysbrand Nusse,
- Michel Dosch,
- Isabel Büchi,
- Daniel Sanchez-Taltavull,
- Heather Dawson,
- Mercedes Gomez de Agüero,
- Kinji Asahina,
- Paul Kubes,
- Andrew J. Macpherson,
- Deborah Stroka,
- Daniel Candinas
Affiliations
- Joel Zindel
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Jonas Mittner
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Julia Bayer
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Simon L. April-Monn
- Clinical Pathology Division and Translational Research Unit, Institute of Pathology, University of Bern
- Andreas Kohler
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Ysbrand Nusse
- Department of Pharmacology and Physiology and Snyder Institute for Chronic Diseases and Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary
- Michel Dosch
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Isabel Büchi
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Daniel Sanchez-Taltavull
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Heather Dawson
- Clinical Pathology Division and Translational Research Unit, Institute of Pathology, University of Bern
- Mercedes Gomez de Agüero
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Kinji Asahina
- Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California
- Paul Kubes
- Department of Pharmacology and Physiology and Snyder Institute for Chronic Diseases and Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary
- Andrew J. Macpherson
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Deborah Stroka
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- Daniel Candinas
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern
- DOI
- https://doi.org/10.1038/s41467-021-27612-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Abdominal surgery can often lead to complications including the formation of peritoneal adhesions and the molecular mechanisms underlying this process are still unknown. Here, the authors suggest that bacterial contamination drives adhesion formation through mesothelial EGFR signalling.
