Nature Communications (Jul 2018)
Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
- Daniel Martin,
- Maria S. Degese,
- Lynn Vitale-Cross,
- Ramiro Iglesias-Bartolome,
- Juan Luis Callejas Valera,
- Zhiyong Wang,
- Xiaodong Feng,
- Huwate Yeerna,
- Vachan Vadmal,
- Toshiro Moroishi,
- Rick F. Thorne,
- Moraima Zaida,
- Bradford Siegele,
- Sok C. Cheong,
- Alfredo A. Molinolo,
- Yardena Samuels,
- Pablo Tamayo,
- Kun Liang Guan,
- Scott M. Lippman,
- J. Guy Lyons,
- J. Silvio Gutkind
Affiliations
- Daniel Martin
- Oral and Pharyngeal Cancer Branch, National Institutes of Health
- Maria S. Degese
- Oral and Pharyngeal Cancer Branch, National Institutes of Health
- Lynn Vitale-Cross
- Oral and Pharyngeal Cancer Branch, National Institutes of Health
- Ramiro Iglesias-Bartolome
- Oral and Pharyngeal Cancer Branch, National Institutes of Health
- Juan Luis Callejas Valera
- University of California San Diego, Moores Cancer Center
- Zhiyong Wang
- University of California San Diego, Moores Cancer Center
- Xiaodong Feng
- University of California San Diego, Moores Cancer Center
- Huwate Yeerna
- University of California San Diego, Moores Cancer Center
- Vachan Vadmal
- University of California San Diego, Moores Cancer Center
- Toshiro Moroishi
- Department of Pharmacology, University of California
- Rick F. Thorne
- School of Environmental and Life Sciences, University of Newcastle, and Hunter Cancer Research Alliance
- Moraima Zaida
- Oral and Pharyngeal Cancer Branch, National Institutes of Health
- Bradford Siegele
- Department of Pathology School of Medicine, University of Colorado
- Sok C. Cheong
- Oral Cancer Research Team, Cancer Research
- Alfredo A. Molinolo
- University of California San Diego, Moores Cancer Center
- Yardena Samuels
- Department of Molecular Cell Biology, The Weizmann Institute of Science
- Pablo Tamayo
- University of California San Diego, Moores Cancer Center
- Kun Liang Guan
- University of California San Diego, Moores Cancer Center
- Scott M. Lippman
- University of California San Diego, Moores Cancer Center
- J. Guy Lyons
- Dermatology, Bosch Institute, University of Sydney
- J. Silvio Gutkind
- Oral and Pharyngeal Cancer Branch, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-018-04590-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in the activation of core Hippo kinases and YAP1 inactivation.
