Nature Communications (Jul 2021)
Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex
- Rohit Prakash,
- Thomas Sandoval,
- Florian Morati,
- Jennifer A. Zagelbaum,
- Pei-Xin Lim,
- Travis White,
- Brett Taylor,
- Raymond Wang,
- Emilie C. B. Desclos,
- Meghan R. Sullivan,
- Hayley L. Rein,
- Kara A. Bernstein,
- Przemek M. Krawczyk,
- Jean Gautier,
- Mauro Modesti,
- Fabio Vanoli,
- Maria Jasin
Affiliations
- Rohit Prakash
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- Thomas Sandoval
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- Florian Morati
- Cancer Research Center of Marseille, CNRS, Inserm, Institut Paoli-Calmettes, Aix-Marseille Université
- Jennifer A. Zagelbaum
- Department of Genetics and Development and Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University
- Pei-Xin Lim
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- Travis White
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- Brett Taylor
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- Raymond Wang
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- Emilie C. B. Desclos
- Department of Medical Biology, Amsterdam University Medical Centers
- Meghan R. Sullivan
- Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine
- Hayley L. Rein
- Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine
- Kara A. Bernstein
- Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine
- Przemek M. Krawczyk
- Department of Medical Biology, Amsterdam University Medical Centers
- Jean Gautier
- Department of Genetics and Development and Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University
- Mauro Modesti
- Cancer Research Center of Marseille, CNRS, Inserm, Institut Paoli-Calmettes, Aix-Marseille Université
- Fabio Vanoli
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- Maria Jasin
- Developmental Biology Program, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-24205-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. Here the authors reveal roles for the mouse SWS1–SWSAP1–SPIDR complex in inter-homolog recombination, including during meiosis, and sister chromatid exchange in BLM helicase deficient cells.
