PLoS ONE (Jan 2017)

THPdb: Database of FDA-approved peptide and protein therapeutics.

  • Salman Sadullah Usmani,
  • Gursimran Bedi,
  • Jesse S Samuel,
  • Sandeep Singh,
  • Sourav Kalra,
  • Pawan Kumar,
  • Anjuman Arora Ahuja,
  • Meenu Sharma,
  • Ankur Gautam,
  • Gajendra P S Raghava

DOI
https://doi.org/10.1371/journal.pone.0181748
Journal volume & issue
Vol. 12, no. 7
p. e0181748

Abstract

Read online

THPdb (http://crdd.osdd.net/raghava/thpdb/) is a manually curated repository of Food and Drug Administration (FDA) approved therapeutic peptides and proteins. The information in THPdb has been compiled from 985 research publications, 70 patents and other resources like DrugBank. The current version of the database holds a total of 852 entries, providing comprehensive information on 239 US-FDA approved therapeutic peptides and proteins and their 380 drug variants. The information on each peptide and protein includes their sequences, chemical properties, composition, disease area, mode of activity, physical appearance, category or pharmacological class, pharmacodynamics, route of administration, toxicity, target of activity, etc. In addition, we have annotated the structure of most of the protein and peptides. A number of user-friendly tools have been integrated to facilitate easy browsing and data analysis. To assist scientific community, a web interface and mobile App have also been developed.