Hypoxia-activated probe for NIR fluorescence and photoacoustic dual-mode tumor imaging

Meng Li; Huan Li; Qian Wu; Niu Niu; Jiachang Huang; Lingmin Zhang; Ying Li; Dong Wang; Ben Zhong Tang

iScience (Mar 2021)

Hypoxia-activated probe for NIR fluorescence and photoacoustic dual-mode tumor imaging

Meng Li,
Huan Li,
Qian Wu,
Niu Niu,
Jiachang Huang,
Lingmin Zhang,
Ying Li,
Dong Wang,
Ben Zhong Tang

Affiliations

Meng Li: Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
Huan Li: Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China
Qian Wu: Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
Niu Niu: Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
Jiachang Huang: Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
Lingmin Zhang: Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China
Ying Li: Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China; Corresponding author
Dong Wang: Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China; Corresponding author
Ben Zhong Tang: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, P. R. China; Corresponding author

Journal volume & issue: Vol. 24, no. 3
p. 102261

Abstract

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Summary: Construction of tumor microenvironment responsive probe with more than one imaging modality, in particular toward hypoxia of solid tumors, is an appealing yet significantly challenging task. In this work, we designed a hypoxia-activated probe TBTO (Triphenylamine-Benzothiadiazole-Triphenylamine derivative featuring four diethylamino N-Oxide groups) for in vivo imaging. TBTO could undergo bioreduction in a hypoxic microenvironment to yield compound TBT sharing both near-infrared (NIR) aggregation-induced emission and strong twisted intramolecular charge transfer features, which endows the probe with excellent performance in NIR fluorescence and photoacoustic dual-mode tumor imaging. This study offers useful insights into designing a new generation agent for clinical cancer diagnosis.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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