Scientific Reports (May 2024)

Preoperative smoking and robot-assisted radical cystectomy outcomes & complications in multicenter KORARC database

  • Joongwon Choi,
  • Jooyoung Lee,
  • Yu Been Hwang,
  • Byong Chang Jeong,
  • Sangchul Lee,
  • Ja Hyeon Ku,
  • Jong Kil Nam,
  • Wansuk Kim,
  • Ji Youl Lee,
  • Sung Hoo Hong,
  • Koon Ho Rha,
  • Woong Kyu Han,
  • Won Sik Ham,
  • Sung Gu Kang,
  • Seok Ho Kang,
  • Jong Jin Oh,
  • Young Goo Lee,
  • Tae Gyun Kwon,
  • Tae-Hwan Kim,
  • Seung Hyun Jeon,
  • Sang Hyub Lee,
  • Sung Yul Park,
  • Young Eun Yoon,
  • Yong Seong Lee

DOI
https://doi.org/10.1038/s41598-024-61005-6
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 7

Abstract

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Abstract To investigate the influence of preoperative smoking history on the survival outcomes and complications in a cohort from a large multicenter database. Many patients who undergo radical cystectomy (RC) have a history of smoking; however, the direct association between preoperative smoking history and survival outcomes and complications in patients with muscle-invasive bladder cancer (MIBC) who undergo robot-assisted radical cystectomy (RARC) remains unexplored. We conducted a retrospective analysis using data from 749 patients in the Korean Robot-Assisted Radical Cystectomy Study Group (KORARC) database, with an average follow-up duration of 30.8 months. The cohort was divided into two groups: smokers (n = 351) and non-smokers (n = 398). Propensity score matching was employed to address differences in sample size and baseline demographics between the two groups (n = 274, each). Comparative analyses included assessments of oncological outcomes and complications. After matching, smoking did not significantly affect the overall complication rate (p = 0.121). Preoperative smoking did not significantly increase the occurrence of complications based on complication type (p = 0.322), nor did it increase the readmission rate (p = 0.076). There were no perioperative death in either group. Furthermore, preoperative smoking history showed no significant impact on overall survival (OS) [hazard ratio (HR) = 0.87, interquartile range (IQR): 0.54–1.42; p = 0.589] and recurrence-free survival (RFS) (HR = 1.12, IQR: 0.83–1.53; p = 0.458) following RARC for MIBC. The extent of preoperative smoking (≤ 10, 10–30, and ≥ 30 pack-years) had no significant influence on OS and RFS in any of the categories (all p > 0.05). Preoperative smoking history did not significantly affect OS, RFS, or complications in patients with MIBC undergoing RARC.

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