Synthesis of vinyldihydropyran by cooperative catalysis

Abstract

5-Unsaturated aldehydes with a suitably positioned allylic halide, or phosphate, leaving group undergo doubly-catalyzed cyclization to give dihydropyran derivatives. The cyclization proceeds under the synergetic action of diazabicycloundecene and Pd(PPh3)4. This type of transformation was also accomplished with an aryl ketone. [Projekat Ministarstva nauke Republike Srbije, br. ON172027]

Keywords

• dihydropyran
• cooperative catalysis
• cyclization
• organopalladium reagents