Опухоли женской репродуктивной системы (Sep 2014)

SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY

  • M. B. Kozlova,
  • E. M. Frantziyantz,
  • G. A. Nerodo,
  • R. N. Salatov,
  • R. G. Luganskaya,
  • I. P. Sidorenko,
  • M. V. Kashubina

DOI
https://doi.org/10.17650/1994-4098-2009-0-1-2-29-33
Journal volume & issue
Vol. 0, no. 1-2
pp. 29 – 33

Abstract

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The hormonal background was studied in 32 menopausal patients who had primary breast cancer (Stage III) or its recurrence in the postoperative scar. The patients with the primary process, unlike those with a recurrence, were found to have increased adrenocortical cortisol-forming activity and changed thyroid homeostasis. In both types of the neoplastic process, the blood concentrations of estradi- ol, testosterone, prolactin, follicle-stimulating and luteinizing hormones were disturbed in a substantial number of cases; the distinc- tive feature of the primary process and its recurrence lies in the opposite direction. An association of individual differences in the con- centrations of estradiol and testosterone with the efficiency of neoadjuvant chemotherapy was analyzed in patients with recurrent can- cer.

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