Analysis of Efficacy and Safety of Tick-Borne Encephalitis Vaccines

Abstract

This article provides a review on efficacy and safety of tick-borne encephalitis vaccines licensed in the Russian Federation. It highlights that both Russian and imported tick-borne encephalitis vaccines demonstrate high immunogenicity, safety and epidemiological effectiveness in regions with high vaccine coverage. All licensed tick- borne encephalitis vaccines meet interchangeability criteria in terms of indications for use (with due regard to age limits), medical contraindications, vaccination schedules, vaccine composition, as well as safety, immunological activity and efficacy parameters. Timely and specific prophylaxis help reduce the incidence of tick-borne encephalitis in endemic regions.

Keywords

• tick-borne encephalitis
• preventive vaccination
• immunogenicity
• reactogenicity
• efficacy
• safety
• interchangeability