Next generation plasma proteome profiling to monitor health and disease

Wen Zhong; Fredrik Edfors; Anders Gummesson; Göran Bergström; Linn Fagerberg; Mathias Uhlén

doi:10.1038/s41467-021-22767-z

Nature Communications (May 2021)

Next generation plasma proteome profiling to monitor health and disease

Wen Zhong,
Fredrik Edfors,
Anders Gummesson,
Göran Bergström,
Linn Fagerberg,
Mathias Uhlén

Affiliations

Wen Zhong: Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology
Fredrik Edfors: Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology
Anders Gummesson: Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University
Göran Bergström: Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University
Linn Fagerberg: Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology
Mathias Uhlén: Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology

DOI: https://doi.org/10.1038/s41467-021-22767-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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