Assessment of the ameliorative effect of Hypericum perforatum on olanzapine-induced hepatic oxidative stress and metabolic abnormalities in experimental male albino rats

Abstract

Olanzapine (OLZ), one of the second-generation antipsychotics, is effective in stress accompanying with chronic psychiatric disease. But the effect of chronic long-standing use of OLZ administration on the liver and its association with metabolic side effects plus weight gain is still unclear. The objective of our study was to evaluate the antioxidant effect of Hypericum perforatum (HP) on OLZ-induced oxidative stress, biochemical disturbance, and histological alteration in the rat’s liver. Forty male wistar albino rats were allocated as follows: normal control rats (group 1), rats treated with OLZ at a dose of 27.0 mg/kg/day (group 2), group 3 (treated with HP at a dose of 81.0 mg/kg/day) and group 4 (received HP plus OLZ at the same doses). The results revealed that the OLZ-administration led to a significant elevation (***P < 0.001) in the levels of MDH, blood glucose, triglycerides, total cholesterol, liver function parameters and weight gain while a significant decrease (***P < 0.001) in activities of liver SOD and GSH was found. In addition to structural damage in the liver’s tissue. These findings were evaluated the toxic effects of chronic administration of OLZ. While HP supplementation caused a significant improvement (++P <0.05, +++P < 0.001) in liver biomarkers, metabolic parameters, and oxidative stress index besides inhibit the histological damage of liver tissue.

Keywords

• olanzapine
• hypericum perforatum
• hepatotoxicity
• oxidative stress
• biochemical alterations
• histopathology