Nature Communications (Nov 2022)

Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis

  • Bingzi Dong,
  • Masahiro Hiasa,
  • Yoshiki Higa,
  • Yukiyo Ohnishi,
  • Itsuro Endo,
  • Takeshi Kondo,
  • Yuichi Takashi,
  • Maria Tsoumpra,
  • Risa Kainuma,
  • Shun Sawatsubashi,
  • Hiroshi Kiyonari,
  • Go Shioi,
  • Hiroshi Sakaue,
  • Tomoki Nakashima,
  • Shigeaki Kato,
  • Masahiro Abe,
  • Seiji Fukumoto,
  • Toshio Matsumoto

DOI
https://doi.org/10.1038/s41467-022-34869-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Here, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. Interleukin-11 secreted by the bone acts as a hormone to regulate fat metabolism, in addition to having an autocrine-paracrine effect on bone itself.