The Effects of Capparis Spinosa Leaves on The Histological Findings Associated With The Exposure of Mice to Trichloroacetic Acid

Abstract

The present work was conducted to study the possible protective role of Capparis spinosa leaves and their efficacy against hematological and histological alterations resulted in an animal model intoxicated with trichloroacetis acid ( TCA). Hundred male mice 20-26 gm were divided into 5 groups ; control group , group II treated oraly with honey ( 40 mg / Kg body weight for 3 weeks ) , group III treated orally with a mixture of Capparis spinosa leaves powder and honey ( 40 mg/ Kg for 3 weeks) , group IV treated with TCA in drinking water ( 500 mg / Kg fpr 3 and 6 weeks , then left for 3 weeks for recovery) and group V ( Regeneration group ) treated with TCA for 6 weeks then treated with a mixture of Capparis and honey ( 40 gm /Kg for 3 weeks). Histological examination of spleen sections of mice treated with TCA revealed obvious pathological findings including disorganization of lymphoid follicles , hyperplasia in white pulp , depletion of lymphocyts in red pulp with subcapsular edema , some necrotic cells in white and red pulp , increasing megakarycoytes, haemosiderosis and fibrosis in red pulp and in some lymphoid follocles. Administration of a mixture of Capparis spinosa leaves powder and honey lessened most of the pathological lesions in mice intoxicated with TCA