Developmental Toxicities in Zebrafish Embryos Exposed to Tri-o-cresyl Phosphate
Meng Li,
Congcong Wang,
Wanying Gui,
Peng Wang,
Jierong Chen,
Shaoqi Zuo,
Yanbin Zhao,
Jiayin Dai,
Kun Zhang
Affiliations
Meng Li
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Congcong Wang
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Wanying Gui
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Peng Wang
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Jierong Chen
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Shaoqi Zuo
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Yanbin Zhao
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Jiayin Dai
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Kun Zhang
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
As a widely used plasticizer and fire retardant, tri-o-cresyl phosphate has been commonly found in global water sources, sediments and biota. However, its potential toxicity to aquatic organisms is not fully understood. Here, we assessed its developmental effects by use of a zebrafish (Danio rerio) model at tri-o-cresyl phosphate concentrations between 0.15 and 88.5 μg/L. Diverse impairments of zebrafish embryos, such as altered morphological and physical characteristics and locomotor behaviors, were observed at different tri-o-cresyl phosphate concentrations. Furthermore, swimming behaviors were significantly inhibited at tri-o-cresyl phosphate concentrations ranging from 3.0 μg/L to 88.5 μg/L. The swimming activity during light-to-dark transition significantly increased at tri-o-cresyl phosphate concentrations of 14.5 μg/L to 88.5 μg/L. Taken together, our present data help to clarify the potential developmental toxicity of tri-o-cresyl phosphate that was not yet fully recognized, and thus contribute to its environmental risk assessment.
