Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

Valérie Brügger; Mert Duman; Maëlle Bochud; Emmanuelle Münger; Manfred Heller; Sophie Ruff; Claire Jacob

doi:10.1038/ncomms14272

Nature Communications (Jan 2017)

Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

Valérie Brügger,
Mert Duman,
Maëlle Bochud,
Emmanuelle Münger,
Manfred Heller,
Sophie Ruff,
Claire Jacob

Affiliations

Valérie Brügger: Department of Biology, University of Fribourg
Mert Duman: Department of Biology, University of Fribourg
Maëlle Bochud: Department of Biology, University of Fribourg
Emmanuelle Münger: Department of Biology, University of Fribourg
Manfred Heller: Department of Clinical Research, Proteomics and Mass Spectrometry Core Facility, University of Bern
Sophie Ruff: Department of Biology, University of Fribourg
Claire Jacob: Department of Biology, University of Fribourg

DOI: https://doi.org/10.1038/ncomms14272
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Brüggeret al. identify part of the molecular machinery that controls Schwann cell development after peripheral nerve injury. Inhibiting HDAC1/2 early after injury enhances nerve regeneration and promotes functional recovery.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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