Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

Lisheng Lin; Miho Takahashi-Igari; Yoshiaki Kato; Yoshihiro Nozaki; Mana Obata; Hiromi Hamada; Hitoshi Horigome

doi:10.1155/2017/6570465

Case Reports in Pediatrics (Jan 2017)

Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

Lisheng Lin,
Miho Takahashi-Igari,
Yoshiaki Kato,
Yoshihiro Nozaki,
Mana Obata,
Hiromi Hamada,
Hitoshi Horigome

Affiliations

Lisheng Lin: Department of Child Health, University of Tsukuba, Tsukuba, Japan
Miho Takahashi-Igari: Department of Child Health, University of Tsukuba, Tsukuba, Japan
Yoshiaki Kato: Department of Child Health, University of Tsukuba, Tsukuba, Japan
Yoshihiro Nozaki: Department of Child Health, University of Tsukuba, Tsukuba, Japan
Mana Obata: Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan
Hiromi Hamada: Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan
Hitoshi Horigome: Department of Child Health, University of Tsukuba, Tsukuba, Japan

DOI: https://doi.org/10.1155/2017/6570465
Journal volume & issue: Vol. 2017

Abstract

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We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.

Published in Case Reports in Pediatrics

ISSN: 2090-6803 (Print); 2090-6811 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pediatrics
Website: https://onlinelibrary.wiley.com/journal/2920

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