European Journal of Case Reports in Internal Medicine (Oct 2024)

Nebivolol-induced hepatoxicity: a case report

  • Lynn Srour,
  • Majed Ali,
  • Karam Karam,
  • Elias Fiani

DOI
https://doi.org/10.12890/2024_004866

Abstract

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Nebivolol is a third-generation beta-blocker known for its high selectivity for beta-1 adrenergic receptors and its unique ability to induce vasodilation via nitric oxide (NO) release. Nebivolol, despite its favourable safety profile, can lead to significant liver injury. We describe the case of a 73-year-old hypertensive patient who developed significant liver enzyme elevations following the addition of nebivolol to her treatment regimen. Comprehensive workup ruled out other causes, leading to a diagnosis of drug-induced hepatotoxicity. Discontinuation of nebivolol resulted in normalization of liver enzymes. This case underscores the importance of monitoring liver function during beta-blocker therapy, particularly with nebivolol.

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