Nature Communications (Dec 2019)
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function
- Fengyuan Tang,
- Ruize Gao,
- Beena Jeevan-Raj,
- Christof B. Wyss,
- Ravi K. R. Kalathur,
- Salvatore Piscuoglio,
- Charlotte K. Y. Ng,
- Sravanth K. Hindupur,
- Sandro Nuciforo,
- Eva Dazert,
- Thomas Bock,
- Shuang Song,
- David Buechel,
- Marco F. Morini,
- Alexander Hergovich,
- Patrick Matthias,
- Dae-Sik Lim,
- Luigi M. Terracciano,
- Markus H. Heim,
- Michael N. Hall,
- Gerhard Christofori
Affiliations
- Fengyuan Tang
- Department of Biomedicine, University of Basel
- Ruize Gao
- Department of Biomedicine, University of Basel
- Beena Jeevan-Raj
- Department of Biomedicine, University of Basel
- Christof B. Wyss
- Department of Biomedicine, University of Basel
- Ravi K. R. Kalathur
- Department of Biomedicine, University of Basel
- Salvatore Piscuoglio
- Institute of Pathology, University Hospital Basel
- Charlotte K. Y. Ng
- Institute of Pathology, University Hospital Basel
- Sravanth K. Hindupur
- Biozentrum, University of Basel
- Sandro Nuciforo
- Department of Biomedicine, University of Basel
- Eva Dazert
- Biozentrum, University of Basel
- Thomas Bock
- Biozentrum, University of Basel
- Shuang Song
- Friedrich Miescher Institute for Biomedical Research
- David Buechel
- Department of Biomedicine, University of Basel
- Marco F. Morini
- Department of Biomedicine, University of Basel
- Alexander Hergovich
- UCL Cancer Institute, University College London
- Patrick Matthias
- Friedrich Miescher Institute for Biomedical Research
- Dae-Sik Lim
- Korea Advanced Institute of Science and Technology
- Luigi M. Terracciano
- Institute of Pathology, University Hospital Basel
- Markus H. Heim
- Department of Biomedicine, University of Basel
- Michael N. Hall
- Biozentrum, University of Basel
- Gerhard Christofori
- Department of Biomedicine, University of Basel
- DOI
- https://doi.org/10.1038/s41467-019-13591-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sorafenib treatment in cancer cells.
