Sequence features accurately predict genome-wide MeCP2 binding in vivo

H. Tomas Rube; Wooje Lee; Miroslav Hejna; Huaiyang Chen; Dag H. Yasui; John F. Hess; Janine M. LaSalle; Jun S. Song; Qizhi Gong

doi:10.1038/ncomms11025

Nature Communications (Mar 2016)

Sequence features accurately predict genome-wide MeCP2 binding in vivo

H. Tomas Rube,
Wooje Lee,
Miroslav Hejna,
Huaiyang Chen,
Dag H. Yasui,
John F. Hess,
Janine M. LaSalle,
Jun S. Song,
Qizhi Gong

Affiliations

H. Tomas Rube: Carl R. Woese Institute for Genomic Biology, University of Illinois
Wooje Lee: Department of Cell Biology and Human Anatomy, University of California School of Medicine
Miroslav Hejna: Carl R. Woese Institute for Genomic Biology, University of Illinois
Huaiyang Chen: Department of Cell Biology and Human Anatomy, University of California School of Medicine
Dag H. Yasui: Department of Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California School of Medicine
John F. Hess: Department of Cell Biology and Human Anatomy, University of California School of Medicine
Janine M. LaSalle: Department of Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California School of Medicine
Jun S. Song: Carl R. Woese Institute for Genomic Biology, University of Illinois
Qizhi Gong: Department of Cell Biology and Human Anatomy, University of California School of Medicine

DOI: https://doi.org/10.1038/ncomms11025
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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MeCP2 is critical for proper brain development, and mutations in the gene encoding MeCP2 are responsible for several neurological disorders. Here, the authors show that the previously reported genome-wide preference of MeCP2 to methylated CpGs is in part due to MeCP2's affinity to GC-rich chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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