Nature Communications (Jan 2020)

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

  • Julia Ast,
  • Anastasia Arvaniti,
  • Nicholas H. F. Fine,
  • Daniela Nasteska,
  • Fiona B. Ashford,
  • Zania Stamataki,
  • Zsombor Koszegi,
  • Andrea Bacon,
  • Ben J. Jones,
  • Maria A. Lucey,
  • Shugo Sasaki,
  • Daniel I. Brierley,
  • Benoit Hastoy,
  • Alejandra Tomas,
  • Giuseppe D’Agostino,
  • Frank Reimann,
  • Francis C. Lynn,
  • Christopher A. Reissaus,
  • Amelia K. Linnemann,
  • Elisa D’Este,
  • Davide Calebiro,
  • Stefan Trapp,
  • Kai Johnsson,
  • Tom Podewin,
  • Johannes Broichhagen,
  • David J. Hodson

DOI
https://doi.org/10.1038/s41467-020-14309-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

Read online

Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics in islets and brain.