High-resolution positron emission microscopy of patient-derived tumor organoids

Syamantak Khan; June Ho Shin; Valentina Ferri; Ning Cheng; Julia E. Noel; Calvin Kuo; John B. Sunwoo; Guillem Pratx

doi:10.1038/s41467-021-26081-6

Nature Communications (Oct 2021)

High-resolution positron emission microscopy of patient-derived tumor organoids

Syamantak Khan,
June Ho Shin,
Valentina Ferri,
Ning Cheng,
Julia E. Noel,
Calvin Kuo,
John B. Sunwoo,
Guillem Pratx

Affiliations

Syamantak Khan: Department of Radiation Oncology, Division of Medical Physics, Stanford University School of Medicine
June Ho Shin: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine
Valentina Ferri: Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Stanford University School of Medicine
Ning Cheng: Division of Hematology, Department of Medicine, Stanford University School of Medicine
Julia E. Noel: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine
Calvin Kuo: Division of Hematology, Department of Medicine, Stanford University School of Medicine
John B. Sunwoo: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine
Guillem Pratx: Department of Radiation Oncology, Division of Medical Physics, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-26081-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Positron emission tomography (PET) radiotracers measure the metabolic activity in cancer cells in patients. Here, the authors develop a microscopy method to image organoids using clinical radiotracers, which allows a direct comparison to PET imaging in patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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