Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

Alessandro Pagliuso; Carmen Valente; Lucia Laura Giordano; Angela Filograna; Guiling Li; Diego Circolo; Gabriele Turacchio; Vincenzo Manuel Marzullo; Luigi Mandrich; Mikhail A. Zhukovsky; Fabio Formiggini; Roman S. Polishchuk; Daniela Corda; Alberto Luini

doi:10.1038/ncomms12148

Nature Communications (Jul 2016)

Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

Alessandro Pagliuso,
Carmen Valente,
Lucia Laura Giordano,
Angela Filograna,
Guiling Li,
Diego Circolo,
Gabriele Turacchio,
Vincenzo Manuel Marzullo,
Luigi Mandrich,
Mikhail A. Zhukovsky,
Fabio Formiggini,
Roman S. Polishchuk,
Daniela Corda,
Alberto Luini

Affiliations

Alessandro Pagliuso: Institute of Protein Biochemistry, National Research Council
Carmen Valente: Institute of Protein Biochemistry, National Research Council
Lucia Laura Giordano: Institute of Protein Biochemistry, National Research Council
Angela Filograna: Institute of Protein Biochemistry, National Research Council
Guiling Li: Institute of Protein Biochemistry, National Research Council
Diego Circolo: Institute of Protein Biochemistry, National Research Council
Gabriele Turacchio: Institute of Protein Biochemistry, National Research Council
Vincenzo Manuel Marzullo: IRCCS SDN Istituto di Ricerca Diagnostica e Nucleare
Luigi Mandrich: Institute of Protein Biochemistry, National Research Council
Mikhail A. Zhukovsky: Institute of Protein Biochemistry, National Research Council
Fabio Formiggini: Italian Institute of Technology, Centre for Advanced Biomaterials for Health Care at CRIB
Roman S. Polishchuk: Telethon Institute of Genetics and Medicine (TIGEM)
Daniela Corda: Institute of Protein Biochemistry, National Research Council
Alberto Luini: Institute of Protein Biochemistry, National Research Council

DOI: https://doi.org/10.1038/ncomms12148
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is required for fission of the post-Golgi carrier membrane.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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