Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors

Zhifen Cui; Yu Zhang; Kai Xia; Qinglong Yan; Huating Kong; Jichao Zhang; Xiaolei Zuo; Jiye Shi; Lihua Wang; Ying Zhu; Chunhai Fan

doi:10.1038/s41467-018-06749-2

Nature Communications (Oct 2018)

Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors

Zhifen Cui,
Yu Zhang,
Kai Xia,
Qinglong Yan,
Huating Kong,
Jichao Zhang,
Xiaolei Zuo,
Jiye Shi,
Lihua Wang,
Ying Zhu,
Chunhai Fan

Affiliations

Zhifen Cui: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Yu Zhang: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Kai Xia: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Qinglong Yan: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Huating Kong: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Jichao Zhang: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Xiaolei Zuo: School of Chemistry and Chemical Engineering, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Jiye Shi: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Lihua Wang: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Ying Zhu: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Chunhai Fan: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-018-06749-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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