Nature Communications (Sep 2019)

The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis

  • Ricardo Romero-Moreno,
  • Kimberly J. Curtis,
  • Thomas R. Coughlin,
  • Maria Cristina Miranda-Vergara,
  • Shourik Dutta,
  • Aishwarya Natarajan,
  • Beth A. Facchine,
  • Kristen M. Jackson,
  • Lukas Nystrom,
  • Jun Li,
  • William Kaliney,
  • Glen L. Niebur,
  • Laurie E. Littlepage

DOI
https://doi.org/10.1038/s41467-019-12108-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Breast cancer cells often invade the bone tissue and remain dormant until they are induced to colonize the metastatic site. Here the authors develop an ex vivo co-culture system consisting of bone and cancer cells from mice and show that CXCL5 has a role in metastatic colonization in the bone.