Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

Abstract

The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.

Keywords

• p53 polymorphism
• codon 72
• genetic polymorphism
• cervix cancer
• human papillomavirus