Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses

Abstract

Highlights Recombinant avipoxviruses as putative recombinant vaccines against MPXV. Different prime–boost regimens to improve immunization against orthopoxviruses. Mucosal and intramuscular immunization to enhance the humoral and neutralizing immune response.

Keywords

• Prime-boost immunization regimens
• Recombinant vaccines against MPXV
• Orthopoxvirus vaccines
• Enhancement of the immune response