Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity

Yiwei Shen; Kamala Vanarsa; Zhihua Yin; Zhihua Yin; Ting Zhang; Ting Zhang; Jessica Castillo; Min Dai; Linghua Zou; Linghua Zou; Ling Qin; Jieying Wang; Qiang Guo; Ramesh Saxena; Michelle Petri; Nan Shen; Nan Shen; Nan Shen; Nan Shen; Nan Shen; Zhizhong Ye; Zhizhong Ye; Chandra Mohan; Huihua Ding

doi:10.3389/fimmu.2023.1200167

Frontiers in Immunology (Aug 2023)

Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity

Yiwei Shen,
Kamala Vanarsa,
Zhihua Yin,
Zhihua Yin,
Ting Zhang,
Ting Zhang,
Jessica Castillo,
Min Dai,
Linghua Zou,
Linghua Zou,
Ling Qin,
Jieying Wang,
Qiang Guo,
Ramesh Saxena,
Michelle Petri,
Nan Shen,
Nan Shen,
Nan Shen,
Nan Shen,
Nan Shen,
Zhizhong Ye,
Zhizhong Ye,
Chandra Mohan,
Huihua Ding

Affiliations

Yiwei Shen: Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Kamala Vanarsa: Department of Biomedical Engineering, University of Houston, Houston, TX, United States
Zhihua Yin: Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China
Zhihua Yin: Department of Rheumatology, Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China
Ting Zhang: Department of Biomedical Engineering, University of Houston, Houston, TX, United States
Ting Zhang: Division of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China
Jessica Castillo: Department of Biomedical Engineering, University of Houston, Houston, TX, United States
Min Dai: Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Linghua Zou: Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China
Linghua Zou: Department of Rehabilitation, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China
Ling Qin: Department of Nephrology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Jieying Wang: Clinical Research Unit, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Qiang Guo: Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Ramesh Saxena: Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, United States
Michelle Petri: 0Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Nan Shen: Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Nan Shen: Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China
Nan Shen: 1State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China
Nan Shen: 2Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
Nan Shen: 3Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States
Zhizhong Ye: Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China
Zhizhong Ye: Department of Rheumatology, Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China
Chandra Mohan: Department of Biomedical Engineering, University of Houston, Houston, TX, United States
Huihua Ding: Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fimmu.2023.1200167
Journal volume & issue: Vol. 14

Abstract

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ObjectiveThere is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts.MethodsuL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and a US cohort (n=219) of SLE patients and controls using ELISA. A longitudinal cohort includes 20 active Chinese LN patients.ResultsuL-selectin was significantly increased in active LN patients compared to active non-renal SLE, inactive LN, inactive non-renal SLE, chronic kidney disease patients, and healthy controls. uL-selectin positively correlated with global and renal disease activities and was significantly associated with histological activity index and chronicity index (CI). Low uL-selectin was an independent predictor for high CI. During follow-up, uL-selectin levels decreased significantly in the complete renal remission group.ConclusionuL-selectin is a novel biomarker of disease activity and renal histopathology in LN across multiple ethnicities. It also reflects treatment response in LN patients during follow up.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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