EFFECTS OF IVIG TREATMENT UPON LOCAL AND GENERAL IMMUNITY STATE IN THE PATIENTS WITH ACUTE EPIGLOTTITIS

Abstract

Abstract. This study has shown that intravenous normal human immunoglobulin (IVIG), when included into combined therapy of acute epiglottitis, exerts positive effect upon clinical course of the disease and contributes to normalisation of immune status. Due to IVIG therapy, an increase in IgA and sIgA concentrations is observed in laryngopharynx secretions. Amounts and affinity of serum antibodies to common bacterial antigenic determinant are increased in blood, as well as opsonizing properties of blood serum. Moreover, a higher phagocytic and bactericidal activity of neutrophils is observed with such treatment. Inflammatory as well as degenerative and destructive processes in epiglottis seem to be preventable under the influence of IVIG therapy.

Keywords

• intravenous normal human immunoglobulin
• acute epiglottitis