Nature Communications (Oct 2021)
Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity
- Hagit Achdout,
- Einat. B. Vitner,
- Boaz Politi,
- Sharon Melamed,
- Yfat Yahalom-Ronen,
- Hadas Tamir,
- Noam Erez,
- Roy Avraham,
- Shay Weiss,
- Lilach Cherry,
- Erez Bar-Haim,
- Efi Makdasi,
- David Gur,
- Moshe Aftalion,
- Theodor Chitlaru,
- Yaron Vagima,
- Nir Paran,
- Tomer Israely
Affiliations
- Hagit Achdout
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Einat. B. Vitner
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Boaz Politi
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Sharon Melamed
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Yfat Yahalom-Ronen
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Hadas Tamir
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Noam Erez
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Roy Avraham
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Shay Weiss
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Lilach Cherry
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Erez Bar-Haim
- Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research
- Efi Makdasi
- Departments of Infectious Diseases, Israel Institute for Biological Research
- David Gur
- Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research
- Moshe Aftalion
- Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research
- Theodor Chitlaru
- Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research
- Yaron Vagima
- Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research
- Nir Paran
- Departments of Infectious Diseases, Israel Institute for Biological Research
- Tomer Israely
- Departments of Infectious Diseases, Israel Institute for Biological Research
- DOI
- https://doi.org/10.1038/s41467-021-26113-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Influenza A virus (IAV) and SARS-CoV-2 coinfection is a possible scenario during influenza season. Here, the authors show in a mouse model that IAV infection increases the risk of severe disease upon SARS-CoV-2 infection two days later. IAV vaccination, especially antibody-dependent, protects from severe disease during coinfection.
