Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Lauriane Galle-Treger; Ishwarya Sankaranarayanan; Benjamin P. Hurrell; Emily Howard; Richard Lo; Hadi Maazi; Gavin Lewis; Homayon Banie; Alan L. Epstein; Peisheng Hu; Virender K. Rehan; Frank D. Gilliland; Hooman Allayee; Pejman Soroosh; Arlene H. Sharpe; Omid Akbari

doi:10.1038/s41467-019-08449-x

Nature Communications (Feb 2019)

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Lauriane Galle-Treger,
Ishwarya Sankaranarayanan,
Benjamin P. Hurrell,
Emily Howard,
Richard Lo,
Hadi Maazi,
Gavin Lewis,
Homayon Banie,
Alan L. Epstein,
Peisheng Hu,
Virender K. Rehan,
Frank D. Gilliland,
Hooman Allayee,
Pejman Soroosh,
Arlene H. Sharpe,
Omid Akbari

Affiliations

Lauriane Galle-Treger: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Ishwarya Sankaranarayanan: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Benjamin P. Hurrell: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Emily Howard: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Richard Lo: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Hadi Maazi: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Gavin Lewis: Janssen Research and Development
Homayon Banie: Janssen Research and Development
Alan L. Epstein: Department of Pathology, Keck School of Medicine, University of Southern California
Peisheng Hu: Department of Pathology, Keck School of Medicine, University of Southern California
Virender K. Rehan: Division of Neonatology, Harbor-UCLA Medical Center
Frank D. Gilliland: Department of Preventive Medicine, Division of Environmental Health, University of Southern California
Hooman Allayee: Departments of Preventive Medicine and Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California
Pejman Soroosh: Janssen Research and Development
Arlene H. Sharpe: Department of Microbiology and Immunobiology, Harvard Medical School
Omid Akbari: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/s41467-019-08449-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Type-2 innate lymphoid cells (ILC2s) are an immune population secreting Th2 cytokines playing a role in the regulation of adipose metabolic homeostasis. Here the authors show that engagement of GITR, a member of the TNF superfamily, in activated ILC2s is protective against insulin resistance in both a preventive and a therapeutic manner in the context of obesity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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