Nature Communications (Mar 2017)
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts
- Kuan-lin Huang,
- Shunqiang Li,
- Philipp Mertins,
- Song Cao,
- Harsha P. Gunawardena,
- Kelly V. Ruggles,
- D. R. Mani,
- Karl R. Clauser,
- Maki Tanioka,
- Jerry Usary,
- Shyam M. Kavuri,
- Ling Xie,
- Christopher Yoon,
- Jana W Qiao,
- John Wrobel,
- Matthew A. Wyczalkowski,
- Petra Erdmann-Gilmore,
- Jacqueline E. Snider,
- Jeremy Hoog,
- Purba Singh,
- Beifang Niu,
- Zhanfang Guo,
- Sam Qiancheng Sun,
- Souzan Sanati,
- Emily Kawaler,
- Xuya Wang,
- Adam Scott,
- Kai Ye,
- Michael D. McLellan,
- Michael C. Wendl,
- Anna Malovannaya,
- Jason M. Held,
- Michael A. Gillette,
- David Fenyö,
- Christopher R. Kinsinger,
- Mehdi Mesri,
- Henry Rodriguez,
- Sherri R. Davies,
- Charles M. Perou,
- Cynthia Ma,
- R. Reid Townsend,
- Xian Chen,
- Steven A. Carr,
- Matthew J. Ellis,
- Li Ding
Affiliations
- Kuan-lin Huang
- Department of Medicine, Washington University in St. Louis
- Shunqiang Li
- Department of Medicine, Washington University in St. Louis
- Philipp Mertins
- The Broad Institute of MIT and Harvard
- Song Cao
- McDonnell Genome Institute, Washington University in St. Louis
- Harsha P. Gunawardena
- Department of Biochemistry & Biophysics, University of North Carolina
- Kelly V. Ruggles
- Center for Health Informatics and Bioinformatics, New York University School of Medicine
- D. R. Mani
- The Broad Institute of MIT and Harvard
- Karl R. Clauser
- The Broad Institute of MIT and Harvard
- Maki Tanioka
- Lineberger Comprehensive Cancer Center, University of North Carolina
- Jerry Usary
- Lineberger Comprehensive Cancer Center, University of North Carolina
- Shyam M. Kavuri
- Lester and Sue Smith Breast Center, Baylor College of Medicine
- Ling Xie
- Department of Biochemistry & Biophysics, University of North Carolina
- Christopher Yoon
- Department of Medicine, Washington University in St. Louis
- Jana W Qiao
- The Broad Institute of MIT and Harvard
- John Wrobel
- Department of Biochemistry & Biophysics, University of North Carolina
- Matthew A. Wyczalkowski
- McDonnell Genome Institute, Washington University in St. Louis
- Petra Erdmann-Gilmore
- Department of Medicine, Washington University in St. Louis
- Jacqueline E. Snider
- Department of Medicine, Washington University in St. Louis
- Jeremy Hoog
- Department of Medicine, Washington University in St. Louis
- Purba Singh
- Lester and Sue Smith Breast Center, Baylor College of Medicine
- Beifang Niu
- McDonnell Genome Institute, Washington University in St. Louis
- Zhanfang Guo
- Department of Medicine, Washington University in St. Louis
- Sam Qiancheng Sun
- Department of Medicine, Washington University in St. Louis
- Souzan Sanati
- Department of Pathology and Immunology, Washington University in St. Louis
- Emily Kawaler
- Center for Health Informatics and Bioinformatics, New York University School of Medicine
- Xuya Wang
- Center for Health Informatics and Bioinformatics, New York University School of Medicine
- Adam Scott
- McDonnell Genome Institute, Washington University in St. Louis
- Kai Ye
- McDonnell Genome Institute, Washington University in St. Louis
- Michael D. McLellan
- McDonnell Genome Institute, Washington University in St. Louis
- Michael C. Wendl
- McDonnell Genome Institute, Washington University in St. Louis
- Anna Malovannaya
- Lester and Sue Smith Breast Center, Baylor College of Medicine
- Jason M. Held
- Department of Medicine, Washington University in St. Louis
- Michael A. Gillette
- The Broad Institute of MIT and Harvard
- David Fenyö
- Center for Health Informatics and Bioinformatics, New York University School of Medicine
- Christopher R. Kinsinger
- National Cancer Institute, National Institutes of Health
- Mehdi Mesri
- National Cancer Institute, National Institutes of Health
- Henry Rodriguez
- National Cancer Institute, National Institutes of Health
- Sherri R. Davies
- Department of Medicine, Washington University in St. Louis
- Charles M. Perou
- Lineberger Comprehensive Cancer Center, University of North Carolina
- Cynthia Ma
- Department of Medicine, Washington University in St. Louis
- R. Reid Townsend
- Department of Medicine, Washington University in St. Louis
- Xian Chen
- Department of Biochemistry & Biophysics, University of North Carolina
- Steven A. Carr
- The Broad Institute of MIT and Harvard
- Matthew J. Ellis
- Lester and Sue Smith Breast Center, Baylor College of Medicine
- Li Ding
- Department of Medicine, Washington University in St. Louis
- DOI
- https://doi.org/10.1038/ncomms14864
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable candidates can be identified based on a comprehensive proteogenomic profiling.
