Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

Serena Belluschi; Emily F. Calderbank; Valerio Ciaurro; Blanca Pijuan-Sala; Antonella Santoro; Nicole Mende; Evangelia Diamanti; Kendig Yen Chi Sham; Xiaonan Wang; Winnie W. Y. Lau; Wajid Jawaid; Berthold Göttgens; Elisa Laurenti

doi:10.1038/s41467-018-06442-4

Nature Communications (Oct 2018)

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

Serena Belluschi,
Emily F. Calderbank,
Valerio Ciaurro,
Blanca Pijuan-Sala,
Antonella Santoro,
Nicole Mende,
Evangelia Diamanti,
Kendig Yen Chi Sham,
Xiaonan Wang,
Winnie W. Y. Lau,
Wajid Jawaid,
Berthold Göttgens,
Elisa Laurenti

Affiliations

Serena Belluschi: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Emily F. Calderbank: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Valerio Ciaurro: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Blanca Pijuan-Sala: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Antonella Santoro: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Nicole Mende: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Evangelia Diamanti: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Kendig Yen Chi Sham: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Xiaonan Wang: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Winnie W. Y. Lau: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Wajid Jawaid: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Berthold Göttgens: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge
Elisa Laurenti: Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge

DOI: https://doi.org/10.1038/s41467-018-06442-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Human blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment to date.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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