Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure

Franziska Lehne; Thomas Pokrant; Sabnam Parbin; Gabriela Salinas; Jörg Großhans; Katja Rust; Jan Faix; Sven Bogdan

doi:10.1038/s41467-022-30167-0

Nature Communications (May 2022)

Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure

Franziska Lehne,
Thomas Pokrant,
Sabnam Parbin,
Gabriela Salinas,
Jörg Großhans,
Katja Rust,
Jan Faix,
Sven Bogdan

Affiliations

Franziska Lehne: Institute of Physiology and Pathophysiology, Department of Molecular Cell Physiology, Philipps-University Marburg
Thomas Pokrant: Institute for Biophysical Chemistry, Hannover Medical School
Sabnam Parbin: NGS-Integrative Genomics Core Unit, Department of Human Genetics, University Medical Center Göttingen
Gabriela Salinas: NGS-Integrative Genomics Core Unit, Department of Human Genetics, University Medical Center Göttingen
Jörg Großhans: Department of Biology, Philipps-University Marburg
Katja Rust: Institute of Physiology and Pathophysiology, Department of Molecular Cell Physiology, Philipps-University Marburg
Jan Faix: Institute for Biophysical Chemistry, Hannover Medical School
Sven Bogdan: Institute of Physiology and Pathophysiology, Department of Molecular Cell Physiology, Philipps-University Marburg

DOI: https://doi.org/10.1038/s41467-022-30167-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Calcium serves as an important second messenger in signal transduction to the actin cytoskeleton. Here, we identify EFhD2/Swip-1 as a calcium-dependent actin cross-linker promoting rapid reorganization of actin networks in epithelial wound closure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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