Nature Communications (Sep 2018)
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
- Toma A. Yakulov,
- Abhijeet P. Todkar,
- Krasimir Slanchev,
- Johannes Wiegel,
- Alexandra Bona,
- Martin Groß,
- Alexander Scholz,
- Isabell Hess,
- Anne Wurditsch,
- Florian Grahammer,
- Tobias B. Huber,
- Virginie Lecaudey,
- Tillmann Bork,
- Jochen Hochrein,
- Melanie Boerries,
- Justine Leenders,
- Pascal de Tullio,
- François Jouret,
- Albrecht Kramer-Zucker,
- Gerd Walz
Affiliations
- Toma A. Yakulov
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Abhijeet P. Todkar
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Krasimir Slanchev
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Johannes Wiegel
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Alexandra Bona
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Martin Groß
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Alexander Scholz
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Isabell Hess
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Anne Wurditsch
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Florian Grahammer
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Tobias B. Huber
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Virginie Lecaudey
- Faculty of Biology, University of Freiburg
- Tillmann Bork
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Jochen Hochrein
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg
- Melanie Boerries
- Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg
- Justine Leenders
- Center for Interdisciplinary Research on Medicines (CIRM), Metabolomics Group, University of Liège
- Pascal de Tullio
- Center for Interdisciplinary Research on Medicines (CIRM), Metabolomics Group, University of Liège
- François Jouret
- Division of Nephrology, University of Liège Hospital
- Albrecht Kramer-Zucker
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- Gerd Walz
- Renal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-018-06094-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitochondrial metabolism and glycolysis.
