Cancer Management and Research (Oct 2021)
High Expression of PKM2 Was Associated with the Poor Prognosis of Acute Leukemia
Abstract
Yunxiu Huang,1 Lin-mu Chen,2 Jin-ye Xie,1 Hui Han,1 Bao-fang Zhu,1 Luo-jia Wang,1 Wei-jia Wang1 1Department of Laboratory Medicine, Sun Yat-sen University Affiliated Zhongshan Hospital, Zhongshan, Guangdong Province, People’s Republic of China; 2Department of Pharmacy, Sun Yat-sen University Affiliated Zhongshan Hospital, Zhongshan, Guangdong Province, People’s Republic of ChinaCorrespondence: Wei-jia WangSun Yat-sen University Affiliated Zhongshan Hospital, 2 East of Sun Wen Road, Shi Qi District, Zhongshan, 528403, Guangdong Province, People’s Republic of ChinaTel +86-76089880354Email [email protected]: To explore the clinical significance of plasma pyruvate kinase M2 (PKM2) in assessing the incidence and prognosis of acute leukemia.Methods: Plasma samples from 56 acute myeloid leukemia (AML) patients, 40 acute lymphoblastic leukemia (ALL) patients, and 66 plasma samples from healthy individuals were collected. The level of plasma PKM2 was detected by enzyme-linked immunosorbent assay. The clinical significance of PKM2 in acute leukemia was assessed by analyzing receiver operating characteristic and survival curves.Results: The plasma levels of PKM2 in AML or ALL patients were significantly higher than those in healthy individuals, respectively. PKM2 can be used as a potential diagnostic index with the AUC of 0.827 for AML and 0.837 for ALL. The level of plasma PKM2 in ALL patients with a BCR/ABL-positive genotype was significantly higher than that in patients with a BCR/ABL-negative genotype (p< 0.05). The event-free survival and the overall survival of acute leukemia patients with higher PKM2 expression was worse than those with lower PKM2 expression.Conclusion: This study showed that higher levels of PKM2 was negatively correlated with the prognosis of acute leukemia. Therefore, PKM2 can be used as a potential index to assess the incidence and prognosis of acute leukemia.Keywords: acute leukemia, acute myeloid leukemia, acute lymphoblastic leukemia, pyruvate kinase M2
