RISK FACTORS DISTRIBUTION FOR CONGENITAL ANOMALIES IN ISFAHAN POPULATION: 1998-1999

Abstract

Introduction: Congenital anomalies are a wide category of congenital diseases that have non Genetically cause in about 20 percent of cases. Environmental and teratogenic factors during pregnancy period have main role in these events. Any information a bout the risk distribution of these factors in community is useful and important for health qualifying. Methods: In a case-control study, 500 neonates suffered from congenital anomalies were compared to 2000 healthy neonates matched to cases. Data was collected via a questionnaire completed by interview to neonates mothers. Drug history, vaginal bleeding, X-ray exposure, any infectious disease or febrile status and exposure to trauma during pregnancy, history of familiar marriage and positive family history for congenital anomalies were collected. Data was documented in some doubtful matter by referring to medical documents. Odd's ratio was estimated for every risk factor. Results: Familial marriage was 40.2 percent in cases and 21.2 percent in control group (OR=2. 5). History of vaginal bleeding positive drug history, any febrile status and positive history of trauma in cases group was 10.6, 24.3, 14.7 and 10 percent, respectively. These events were reported in control group about 3.5, 4.7, 1.9 and 1 percent, respectively. Odd's ratios were estimated 3.2, 6.5, 8.9, 10.1 for these four subjects, respectively. Positive family history was reported in 23.3 percent of cases to comparison to control group 3.9 percent (OR=7.5). Discussion: It seems that congenital anomalies in our community need more attention about their risk factors control. Health education and primary prevention have a major role in this subject.

Keywords

• Congenital Anomalies, Isfahan, Case-Control Study, Odd's ratio